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 | 濉戞枡 | 姍¤兌 | 綰ょ淮 | 娑傛枡涓庢補(bǔ)澧?/a> | 鑳剁矘鍓?/a> | 澶嶅悎鏉愭枡 | 鐭沖寲 | 鍖栧伐 | 浠櫒浠〃 | 鏂頒駭涓?/a> | 涓撻 | 榪斿洖棣栭〉 |
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| 濉戞枡 | 姍¤兌 | 綰ょ淮 | 娑傛枡涓庢補(bǔ)澧?/a> | 鑳剁矘鍓?/a> | 澶嶅悎鏉愭枡 | 鐭沖寲 | 鍖栧伐 | 浠櫒浠〃 | 鏂頒駭涓?/a> | 涓撻 | 榪斿洖棣栭〉 |
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鐐庣棁鎬ц偁鐥咃紙IBD錛夋槸涓綾繪參鎬с佽繘琛屾у拰鍏嶇柅浠嬪鐨勮偁閬撶柧鐥咃紝涓昏鍖呮嫭鍏嬬綏鎭╃梾鍜屾簝鐤℃х粨鑲犵値銆傜敱浜庣値鐥囨ц偁鐥呯殑鐥呭洜涓嶆槑錛屾棭鏈熻瘖鏂拰姝ｇ‘澶勭悊鏄敼鍠勯鍚庣殑鍏抽敭銆?/span>鐩墠鐐庣棁鎬ц偁鐥呭湪鍩虹鐮旂┒涓瓨鍦ㄨ瘎浠鋒墜孌電浉瀵圭己涔忋佸崟涓鐨勯棶棰橈紝鑰屽湪涓村簥瀹炶返涓己涔忚兘澶熷噯紜瘑鍒梾鐏跺茍寮曞鎵嬫湳鍒囬櫎鐨勬帰閽堛?/span>榪戠孩澶?/span>II鍖猴紙900-1880 nm錛夎崸鍏夋垚鍍忕浉姣旇繎綰㈠I鍖猴紙700-900 nm錛夌粍緇囨暎灝勫皬銆佺┛閫忔繁搴﹀ぇ銆佺粍緇囪嚜鑽у厜浣庯紝浠庤屽湪鎴愬儚涓婂叿澶囨椂闂寸┖闂村垎杈ㄧ巼楂樸佷俊鍙瘋儗鏅瘮楂樺強(qiáng)鎴愬儚娣卞害娣辯殑浼樼偣錛屽湪鐢熺墿鎴愬儚灝ゅ叾鏄椿浣撴垚鍍忎腑鍏鋒湁鍏剁嫭鐗逛紭鍔匡紝鑰屽叾鎺㈤拡鐨勫紑鍙戞槸鍒剁害璇ユ妧鏈墜孌靛彂灞曠殑鍏抽敭闂涔嬩竴銆傜洰鍓嶅紑鍙戠殑榪戠孩澶?/span>II鍖鴻崸鍏夋帰閽堜腑錛屾湁鏈鴻仛闆嗚瀵煎彂鍏夛紙AIE錛夋潗鏂欏洜鍏剁ǔ瀹氶珮銆佽崸鍏変寒搴﹀己銆佷嬌鐢ㄦ柟渚褲佺敓鐗╀翰瀹規(guī)уソ絳変紭鍔匡紝鏄棰嗗煙鐨勭爺絀剁儹鐐廣?/span>
榪戞湡錛屾禉姹熷ぇ瀛﹀尰瀛﹂櫌闄勫睘閭甸稿か鍖婚櫌鏋楄緣鏁欐巿璇鵑緇勩佹禉姹熷ぇ瀛﹀厜鐢?shù)瀛﹂櫌閽遍獜鏁欐巿璇鹃缁勩侀娓腑鏂囧ぇ瀛︼紙娣卞湷錛夊攼鏈繝闄㈠＋鍥㈤槦鍜屽崡寮澶у榻愯抗鏁欐巿鍦?/span>Advanced Healthcare Materials涓婂彂琛ㄤ簡(jiǎn)棰樹負(fù)鈥?/span>Aggregation-Induced Emission (AIE) Nanoparticles-Assisted NIR-II Fluorescence Imaging-Guided Diagnosis and Surgery for Inflammatory Bowel Disease (IBD)鈥?span style="font-family:瀹嬩綋;">鐨勬枃绔狅紙DOI: 10.1002/adhm.202101043錛夈?/span>閽堝鐩墠鐐庣棁鎬ц偁鐥呯爺絀朵腑鐨勯毦鐐癸紝鐮旂┒閫夌敤鍚嶄負(fù)BPN-BBTD鐨?/span>榪戠孩澶?/span>II鍖?/span>AIE鑽у厜鎺㈤拡錛屽寘瑁瑰埌涓や翰鎬ц仛鍚堢墿Pluronic F-127涓紝鍊熷姪榪戠孩澶栦簩鍖洪珮絀塊忔繁搴︺侀珮淇″彿鑳屾櫙姣斻佷綆緇勭粐鑷崸鍏夌殑浼樺娍錛?/span>浠庡叏鏂扮淮搴﹀IBD灝忛紶妯″瀷鐤劇梾榪涘睍鍜岃嵂鐗╁共棰勫弽搴?/span>榪涜璇勪及錛堝浘1錛夈傝鐮旂┒榪?/span>棣栨鍦ㄥ姩鐗╁眰闈?/span>瀹炵幇浜?jiǎn)杩懢U㈠浜屽尯鑽у厜鎴愬儚寮曞涓嬬殑IBD鐥呭彉鑲犳鐨勭簿鍑嗗畾浣嶅拰鍒囬櫎錛?/span>鎻愮ずAIE綰崇背棰楃矑鍦ㄧ値鐥囨ц偁鐥呯殑鎵嬫湳瀵艱埅涓叿鏈夎緝澶у簲鐢ㄥ墠鏅?/span>錛堝浘2錛夈傛渶鍚庯紝涓虹爺絀?/span>BPN-BBTD綰崇背棰楃矑鍦ㄨ偁澹佸唴鐨勫垎甯冿紝璇ュ洟闃熶嬌鐢ㄤ簡(jiǎn)閽遍獜鏁欐巿璇鵑緇勪笌瀹佹嘗鑸滃畤浠櫒鏈夐檺鍏徃鍚堜綔鐮斿彂鐨勫晢鐢ㄧ數(shù)鍔ㄨ繎綰㈠浜屽尯鑽у厜瀹藉満鏄懼井闀滐紙NIR II-MS, Sunny Optical Technology (Group) Co., LTD錛夈傝濂楄澶囨棤闇灝嗙粍緇囧埗澶囨垚鐥呯悊鍒囩墖錛屽嵆鍙緇勭粐鍐呯撼綾抽綺掍俊鍙瘋繘琛岀洿鎺ユ帰嫻嬶紝鐮旂┒淇″彿鍒嗗竷瑙勫緥銆傜粨鏋滆〃鏄?/span>AIE綰崇背棰楃矑涓昏鑱氶泦鍦ㄧ矘鑶滃眰鍜岀矘鑶滀笅灞傦紝涓庣梾鐞嗗垏鐗囦腑鎻愮ず鐨?/span>鐐庣棁閮ㄤ綅涓鑷達(dá)紙鍥?/span>3錛夈?/span>
鏈枃絎竴浣滆呬負(fù)嫻欐睙澶у鍏夌數(shù)瀛﹂櫌鍗氬＋鍚庢▕娼囬渼鍗氬＋錛屽叡鍚岀涓浣滆呬負(fù)嫻欐睙澶у鍖誨闄㈤檮灞為偟閫稿か鍖婚櫌鍗氬＋鐮旂┒鐢熷鍚摥銆傛鐮旂┒寰楀埌鍥藉鑷劧縐戝鍩洪噾銆佹禉姹熺渷閲嶇偣鐮斿彂璁″垝絳?/span>欏圭洰璧勫姪鏀寔銆?/span>
鍥?/span>1 BPN-BBTD@F127 綰崇背棰楃矑鐨勫埗澶囥?/span>IBD灝忛紶鐨勮繎綰㈠浜屽尯璇婃柇鍜岃崸鍏夊鑸墜鏈?/span>
鍥?/span>2 榪戠孩澶栦簩鍖鴻崸鍏夊紩瀵間笅鐨勭梾鍙樿偁孌靛垏闄?/span> A)榪戠孩澶栦簩鍖鴻崸鍏夊紩瀵兼墜鏈ず鎰忓浘B) IBD灝忛紶鑲犳澶т綋褰㈡併?/span>C)IBD灝忛紶鑲犳鐨勮繎綰㈠浜屽尯鏄懼儚銆?/span>D,E)鍏鋒湁鎴栦笉鍏鋒湁榪戠孩澶栦簩鍖轟俊鍙風(fēng)殑IBD灝忛紶鑲犳H&E鏌撹壊銆?/span>F-i)793 nm 嬋鍏夋縺鍙戜笅錛?/span>鐐庣棁鑲犳綺懼噯瀹氫綅錛?/span>ii)鐥呭彉鑲犳鍒囬櫎錛?/span>iii)鑲犲鍓嶄晶鍚誨悎錛?/span>iv)鑲犲鍚庝晶鍚誨悎銆?/span>
鍘熸枃閾炬帴
https://onlinelibrary.wiley.com/doi/10.1002/adhm.202101043