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  復(fù)旦大學(xué)高分子科學(xué)系陳國頌-江明課題組最近幾年關(guān)注通過小分子參與的非共價(jià)相互作用調(diào)控蛋白質(zhì)自組裝，陸續(xù)獲得了規(guī)整的蛋白質(zhì)框架晶體和微米管等納米結(jié)構(gòu)。這一研究成果是她們與德國海姆霍茲柏林材料與能源研究所 (HZB) Matthias Ballauff教授和陸琰教授等經(jīng)密切協(xié)作而得，已有合作文章發(fā)表。

  為了進(jìn)一步理解上述組裝過程的機(jī)理，兩課題組決定聯(lián)合聘請一位博士后，從事此蛋白質(zhì)自組裝過程的理論研究。擬采用計(jì)算機(jī)模擬，理解組裝進(jìn)程中的熱量變化，從而分析組裝中多種非共價(jià)相互作用的協(xié)同貢獻(xiàn)，并進(jìn)一步對組裝結(jié)果進(jìn)行預(yù)測。希望候選者具有軟物質(zhì)和分子動(dòng)力學(xué)模擬方面的知識背景。該工作將主要在復(fù)旦大學(xué)完成，期間將赴德方進(jìn)行每年一個(gè)月的學(xué)習(xí)交流。博士后研究期間的待遇參照聚合物分子工程國家重點(diǎn)實(shí)驗(yàn)室和復(fù)旦大學(xué)高分子系近年的標(biāo)準(zhǔn)，即稅前年薪18-20萬，并享有其它相關(guān)優(yōu)惠政策。請感興趣的同學(xué)發(fā)簡歷到guosong@fudan.edu.cn。

  A joint postdoctoral position from Macromolecular Science Department, Fudan University and Helmholtz Zentrum Berlin für Materialien und Energie.

  The research group led by Guosong Chen and Ming Jiang at Department of Macromolecular Science, Fudan University in recent years has focused on protein assembly by the aid of its interactions with well-designed small molecules. They obtained highly ordered structures of protein crystalline frameworks and microtubules. These results were achieved via their tight collaboration with Profs. Matthias Ballauff and Yan Lu from Helmholtz Zentrum Berlin für Materialien und Energie (HZB). Our joint papers have been published in high-level peer-reviewed journals. To deepen our understanding in the mechanism of these unique protein assembly processes, we expect to have a postdoctor working with us to perform theory study on this system. We plan to utilize computer simulation to understand the heat change of the process, then further analysis the cooperative effects of different non-covalent interactions and finally to predict assembly results. We are looking for a young person who has a passion for this type of research with background of soft matter and molecular simulation. The work will be mainly performed at Fudan University with one-month working visits per year to HZB. The pre-tax salary will be around 180,000-200,000 yuan per year, following the recent criteria made by State Key Laboratory of Molecular Engineering of Polymers and department of Macromolecular Science, Fudan University. For further information, please contact Prof. Guosong Chen, guosong@fudan.edu.cn.